Description
Hemostatic Effect
The specific mechanism of action of chitosan remains undiscovered but data suggest about three possible way to control bleeding:
- Sorption of plasma
- erythrocytes coagulation
- platelet adhesion, aggregation and activation
Hydron (H+) Reinforced Chitosan: Chitosan with enhanced positive charge
Converts amino group (-NH2) in chitosan fiber molecular chain to positively charged amino group (-NH3+)
Chitosan with enhanced positive charge has more enhanced performance than before.
Absorbency & Gelation
Nexoseal (HR-Chitosan dressing) vs other company dressing (n-Chitosan)
List of Efficacy Assessment
– 15N NMR measurement of positive charged amino group (-NH3+)
– Bacterial reduction rate test
– In vivo : Hemostatic test using pig bleeding model
– In vitro : Blood clotting test
– Determination of adsorption property – Detector tube method
– EN 13726-1 : Test methods for primary wound dressings. Aspects of absorbency
Structure analysis
Anti-microbial activity
Bacterial reduction rate test
Antimicrobial effect against Super bacteria(MRSA): 99.9%


Hemostatic test
Blood clotting test
Hemostatic test using pig bleeding model
Toxic molecule adsorption test
Gas detector tube method
Ammonia / Trimethyl amine
Absorbency & Gelation test
EN 13726-1 : Test methods for primary wound dressings. Aspects of absorbency